![]() Role of nitric oxide and endothelial dysfunction The role of the gut is also being explored as a source of oxidative stress which aggravates existing pancreatic inflammation. Preventing and treating pancreatitis thus require almost opposite approaches. 2,3 The onset of pancreatitis is marked by a lack of NO, whereas the acutely inflamed state is marked by an abundance of NO. Nitric oxide (NO) and its impact on micro-circulation appear to play a pivotal role in the pathogenesis of the condition. Part of the confusion surrounding pancreatitis may stem from the fact that the conditions that incite it vanish once the organ has become inflamed. But enough laboratory evidence has accumulated to formulate a likely model of pathogenesis. There is confusion in the veterinary literature about the definitions of acute and chronic pancreatitis, and there are very few studies on the pathophysiology of naturally-occurring pancreatitis in dogs and cats. Thus, any attempt to formulate an evidence-based approach to pancreatitis, whether using drugs, diet or natural therapies, must begin with a review of the current understanding of the disease’s pathophysiology. The prescription of low-fat kibble and canned foods, although common, is largely untested. 1ĭespite the importance of pancreatitis as a clinical syndrome, almost no trials of diets or drugs exist for its treatment and prevention, except for the critically ill patient. ![]() At the other end of the spectrum, chronic pancreatitis in either dogs or cats can cause refractory pain and progressive exocrine and endocrine functional impairment. The acute end of the disease spectrum is associated with high mortality, although there is good potential for complete recovery of organ structure and function if the animal survives. ![]() However, its causes and pathophysiology remain poorly understood, except to say that it is usually a sterile condition. ![]() Pancreatitis is commonly diagnosed and treated in small animal veterinary medicine. Herbal medicines and low-fat meat and vegetable diets can prevent pancreatitis in dogs and cats, and can also be used to resolve acute and chronic stages of the disease. ![]()
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